Last update
5/27/2025

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size:  1 Veg Capsule
Amount Per Serving
%DV
 Vitamin E (as d-alpha Tocopheryl Succinate)
268 mg
1787%

Top Medical Research Studies

9
Vitamin E alleviates leg cramps
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.

Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.

Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.

After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.

Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.

However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.

Most Useful Reviews

9
Eliminated leg cramps
1 people found this helpful
My wife experienced severe leg cramps during pregnancy, and after taking this vitamin supplement (along with 2000 mg of Vitamin C), the pain ceased completely within two weeks and did not return until delivery. We also included other vitamins, but this product was key. Highly recommended!
9
No leg pain
1 people found this helpful
This product has significantly improved my circulation, completely removing the shooting pain in my legs. I take three tablets each morning, and since starting this regimen, the discomfort has vanished.
7.5
Eased leg cramps
1 people found this helpful
I take this to help with my leg cramps. It has slightly eased them, and I've noticed improved skin growth and suppleness. There’s no odd aftertaste, and the capsule is easy to swallow. The packaging is well-sealed, contains high-quality ingredients, and only requires a single dose each day.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
  • All Researches
9
Vitamin E alleviates leg cramps
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.

Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.

Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.

After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.

Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.

However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.

User Reviews

USERS' SCORE
Good
Based on 4 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Eliminated leg cramps
1 people found this helpful
My wife experienced severe leg cramps during pregnancy, and after taking this vitamin supplement (along with 2000 mg of Vitamin C), the pain ceased completely within two weeks and did not return until delivery. We also included other vitamins, but this product was key. Highly recommended!
9
No leg pain
1 people found this helpful
This product has significantly improved my circulation, completely removing the shooting pain in my legs. I take three tablets each morning, and since starting this regimen, the discomfort has vanished.
7.5
Eased leg cramps
1 people found this helpful
I take this to help with my leg cramps. It has slightly eased them, and I've noticed improved skin growth and suppleness. There’s no odd aftertaste, and the capsule is easy to swallow. The packaging is well-sealed, contains high-quality ingredients, and only requires a single dose each day.
7.5
Slightly eased cramps
I use this for leg cramps. It has made them somewhat easier to manage, and I’ve seen a nice effect on my skin’s elasticity. There’s no strange aftertaste, and it’s easy to swallow. It comes in secure packaging and requires only one daily dose of high-quality ingredients.

Frequently Asked Questions

9
Eliminated leg cramps
1 people found this helpful
My wife experienced severe leg cramps during pregnancy, and after taking this vitamin supplement (along with 2000 mg of Vitamin C), the pain ceased completely within two weeks and did not return until delivery. We also included other vitamins, but this product was key. Highly recommended!
7.5
Eased leg cramps
1 people found this helpful
I take this to help with my leg cramps. It has slightly eased them, and I've noticed improved skin growth and suppleness. There’s no odd aftertaste, and the capsule is easy to swallow. The packaging is well-sealed, contains high-quality ingredients, and only requires a single dose each day.
7.5
Slightly eased cramps
I use this for leg cramps. It has made them somewhat easier to manage, and I’ve seen a nice effect on my skin’s elasticity. There’s no strange aftertaste, and it’s easy to swallow. It comes in secure packaging and requires only one daily dose of high-quality ingredients.
9
No leg pain
1 people found this helpful
This product has significantly improved my circulation, completely removing the shooting pain in my legs. I take three tablets each morning, and since starting this regimen, the discomfort has vanished.
7
Vitamin E effective for leg cramps
We explored the effects of vitamin E on leg cramps through a controlled double-blind study involving 40 dialysis patients.

After a two-month placebo washout, participants were split into two groups receiving either quinine or vitamin E.

Both treatments significantly reduced the number of leg cramps. With average monthly cramps dropping to around 3.3 for vitamin E and 3.6 for quinine, the findings indicate both options were effective.

However, since quinine has potential side effects, vitamin E is recommended as the first-line treatment for leg cramps in this population.
9
Vitamin E alleviates leg cramps
We investigated the impact of vitamin E on treating frequent and severe nocturnal leg cramps. Patients received 100 I.U. of d, alpha-tocopheryl acetate three times daily before meals.

Remarkably, nearly all participants reported prompt relief from their symptoms. This group included 24 patients with leg cramps and a couple with "restless legs" syndrome.

Given that nocturnal leg cramps can be distressing and treatments are often unsatisfactory, these findings are particularly noteworthy.
7
Vitamin E shows limited effectiveness
We examined the effectiveness of various treatments for leg cramps, focusing particularly on vitamin E. While quinine has long been a go-to option, its use has significantly decreased due to safety concerns and mixed results in studies. Our review highlighted that although vitamin E might show potential benefits for leg cramps in patients on dialysis, the evidence is not robust across all populations. Therefore, we should consider other medications, like verapamil or gabapentin, before reverting to quinine.

References

  1. Guay DR. Are there alternatives to the use of quinine to treat nocturnal leg cramps?. Consult Pharm. 2008;23:141.
  2. Roca AO, Jarjoura D, Blend D, Cugino A, Rutecki GW, et al. Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO J. 1992;38:M481.
  3. Ayres S, Mihan R. Leg cramps (systremma0 and "restless legs" syndrome. Response to vitamin E (tocopherol). Calif Med. 1969;111:87.
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